Mutagenicity Studies

Genotoxicity is the study of the effect of chemicals on nucleic acid stability. The branch of genetic toxicology has evolved in response to the concern that certain chemicals have been found to induce mutations in various experimental systems. These chemicals are likely to affect the incidence of heritable disease in man and/or be potentially carcinogenic. Various tests based on diversified mutagenic effects have been recommended by The Organisation for Economic Co-operation and Development (OECD) for evaluation of mutagenic potential of the test chemicals.

 

Rotam has extensive experience and expertise in genotoxicity. We have a well-organised, purpose-built facility to conduct all the standard in vitro genetic toxicology assays. Each assay uses protocols that comply with harmonized international guidelines.

 

Genetic Toxicology Studies

  • AMES
  • In vitro micronucleus
  • In vitro chromosome aberration
  • In vitro gene mutation
  • In vitro skin irritation
  • In vitro skin corrosion
  • In vitro skin sensitization
  • In vitro eye irritation
  • In vitro eye corrosion

 

Rotam Research Lab Video (24Feb2020)